JAST
2012 March;3(1):72-80.
Published online 2012 March 01.
doi:http://dx.doi.org/10.5355/JAST.2012.72
|
| Copyright ⓒ 2010 Journal of Analytical Science & Technology |
| Functions of Burkholderia virulence factors: Input from proteomics and DNA microarray analyses |
| Kumutha Malar Vellasamy1, Vanitha Mariappan1, Onn Hashim2,3, Jamuna Vadivelu1* |
1Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kulala Lumpur Malaysia
2Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kulala Lumpur Malaysia
3University of Malaya Centre for Proteomics Research (UMCPR), Faculty of Medicine, University of Malaya, 50603 Kulala Lumpur Malaysia
|
|
Corresponding Author:
Jamuna Vadivelu ,Tel: 603-79676662, Fax: 603-79676671, Email: jamuna@ummc.edu.my |
 |
ABSTRACT |
 |
|
| Burkholderia spp. consists of organisms that are extremely diverse and versatile with a natural habitat in the soil. Members of this genus, which include B. pseudomallei, B. mallei, B. thailandensis and B. cepacia, are capable of causing severe, life threatening opportunistic infection in patients who are immunocompromised. The underlying virulence mechanisms of the bacteria, their interactions with the host and the host defense mechanisms may be reflected by changes of the expression of proteins of both the pathogen as well as the host. In this article, we reviewed the current knowledge on interactions of Burkholderia spp. pathogens with their host mainly from the perspective of data that was generated from recent proteomics and DNA microarray investigations. |
|
|
TABLES |
|
|
|
Table.1
Differentially expressed proteins of B. pseudomallei and B. thailandensis. Adapted and modified from (Wongtrakoongate et al. (2007) [45]). |
|
|
Table.2
Comparison of protein expression the two different clonal isolates of B. cenocepacia |
|
|
|
 |
 Free archive |
|
Anyone may access any past or current articles without logging in.
|
| Register for e-submission |
|
Register here to access the e-submission system of JAST for authors and reviewers.
|
| Journal e-mail Alerts |
|
Don't forget to sign up for journal e-mail alerts so you can keep up to date with all the articles as they are published.
|
| Manuscript Submission |
|
To submit a manuscript, please visit the JAST e-submission management system at http://submit.jastmag.org, read the Instructions for Authors, and log into the JAST e-submission system. For assistance with manuscript submission, please contact: cheong@kbsi.re.kr.
|
|
 |
|
|
|